Catecholamines-crafty weapons in the inflammatory arsenal of immune/inflammatory cells or opening pandora's box?

@article{Flierl2008CatecholaminescraftyWI,
  title={Catecholamines-crafty weapons in the inflammatory arsenal of immune/inflammatory cells or opening pandora's box?},
  author={Michael Flierl and Daniel Rittirsch and Markus S Huber-Lang and Jatindra Sarma and Peter A Ward},
  journal={Molecular medicine},
  year={2008},
  volume={14 3-4},
  pages={
          195-204
        }
}
It is well established that catecholamines (CAs), which regulate immune and inflammatory responses, derive from the adrenal medulla and from presynaptic neurons. Recent studies reveal that T cells also can synthesize and release catecholamines which then can regulate T cell function. We have shown recently that macrophages and neutrophils, when stimulated, can generate and release catecholamines de novo which, then, in an autocrine/paracrine manner, regulate mediator release from these… CONTINUE READING

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