Catecholamines and endogenous opioids in ventral tegmental self-stimulation reward.

@article{Wolfswinkel1988CatecholaminesAE,
  title={Catecholamines and endogenous opioids in ventral tegmental self-stimulation reward.},
  author={Leo van Wolfswinkel and Wilhelm Seifert and Jan M van Ree},
  journal={Pharmacology, biochemistry, and behavior},
  year={1988},
  volume={30 3},
  pages={589-95}
}
Midbrain dopaminergic pathways and opioid receptor systems have been implicated in the reward experienced in electrical intracranial self-stimulation behavior. In the present experiment, the influence of graded doses of the dopamine antagonist haloperidol and of the agonist cocaine were investigated on electrical self-stimulation reward, elicited by electrodes located in the ventral tegmental area. A threshold method, which is rather insensitive for aspecific motor effects, was applied to… CONTINUE READING