Catecholaminergic polymorphic ventricular tachycardia: recent mechanistic insights.

@article{Kontula2005CatecholaminergicPV,
  title={Catecholaminergic polymorphic ventricular tachycardia: recent mechanistic insights.},
  author={Kimmo K Kontula and P{\"a}ivi J. Laitinen and Annukka Lehtonen and Lauri Toivonen and Matti T. Viitasalo and Heikki Swan},
  journal={Cardiovascular research},
  year={2005},
  volume={67 3},
  pages={
          379-87
        }
}
Cardiac excitation-contraction coupling occurs by a calcium ion-mediated mechanism in which the signal of action potential is converted into Ca2+ influx into the cardiomyocytes through the sarcolemmal L-type calcium channels. This is followed by Ca2+-induced release of additional Ca2+ ions from the lumen of the sarcoplasmic reticulum into the cytosol via type 2 ryanodine receptors (RyR2). RyR2 channels form large complexes with additional regulatory proteins, including FKBP12.6 and… CONTINUE READING
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