Catecholamine inhibition of Ca2+-induced insulin secretion from electrically permeabilised islets of Langerhans.

Abstract

Noradrenaline (1-10 microM) inhibited Ca2+-induced insulin secretion from electrically permeabilised islets of Langerhans with an efficacy similar to that for inhibition of glucose-induced insulin secretion from intact islets. The inhibition of insulin secretion from permeabilised islets was blocked by the alpha 2-adrenoreceptor antagonist, yohimbine. Adenosine 3',5'-cyclic monophosphate (cAMP) did not relieve the noradrenaline inhibition of Ca2+-induced secretion from the permeabilised islets, although noradrenaline did not affect the secretory responses to cAMP at substimulatory (50 nM) concentrations of Ca2+. These results suggest that catecholamines do not inhibit insulin secretion solely by reducing B-cell adenylate cyclase activity, and imply that one site of action of noradrenaline is at a late stage in the secretory process.

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@article{Jones1987CatecholamineIO, title={Catecholamine inhibition of Ca2+-induced insulin secretion from electrically permeabilised islets of Langerhans.}, author={Peter R. M. Jones and Julie Fyles and Shanta Jean Persaud and Simon L. Howell}, journal={FEBS letters}, year={1987}, volume={219 1}, pages={139-44} }