Catecholamine-induced lipolysis in adipose tissue and skeletal muscle in obesity

  title={Catecholamine-induced lipolysis in adipose tissue and skeletal muscle in obesity},
  author={Johan W. E. Jocken and Ellen E. Blaak},
  journal={Physiology \& Behavior},

Figures and Tables from this paper

Regulation of Lipolysis By Perilipin : influence of Obesity and Exercise Training
Exercise training increases perilipin protein content in lean men which appears to be a key component for a reduced β-adrenergic responsiveness in SED compared to lean, and it appears that acute exercise increases ATGL and perilipIn in obese men.
Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans
The data indicate that altered ATGL and HSL expression in skeletal muscle could promote DAG accumulation and disrupt insulin signaling and action, and Targeting skeletal muscle lipases may constitute an interesting strategy to improve insulin sensitivity in obesity and type 2 diabetes.
Novel evidence is provided that defective adrenergic receptor signaling combined with upregulation of ATGL and suppression of HSL and AMPK signaling mediate HFD-induced alterations in lipolysis and lipid utilization in VC and SC adipocytes, which may play an important role in defective lipid mobilization and metabolism seen in diet-induced obesity.
Skeletal muscle lipase content and activity in obesity and type 2 diabetes.
The data do not support an important role of total muscle DAG content in the development of insulin resistance in obese men and suggest incomplete lipolysis in skeletal muscle tissue.
Schisandrin B regulates lipid metabolism in subcutaneous adipocytes
This study found that Sch B increased HSL phosphorylation, reduced glycerolipid levels and increased fatty acid oxidation gene expressions in the subcutaneous adipocytes in the DIO mice, and significantly reduced the sub cutaneous adipocyte sizes, subCutaneous adipose tissue mass and body weight of the mice.
IL-15 concentrations in skeletal muscle and subcutaneous adipose tissue in lean and obese humans: local effects of IL-15 on adipose tissue lipolysis.
Although the purpose was to examine whether SkM and/or subcutaneous adipose tissue (SCAT) IL-15 concentrations were correlated with SCAT lipolysis in lean and obese humans and determine whether IL-20 perfusion could induce lipolytic responses, this work found no support for a human IL- 15 SkM-blood-adipose tissue axis and found IL-16 may be produced in/act on the abdominal SCAT depot.
Adrenergically and non-adrenergically mediated human adipose tissue lipolysis during acute exercise and exercise training.
Catecholamine-mediated lipolysis may be blunted during exercise in obese IR men but could not be improved by exercise intervention, despite an improved metabolic profile and body composition.
Metabolic inflexibility of white and brown adipose tissues in abnormal fatty acid partitioning of type 2 diabetes.
Novel molecular imaging techniques now demonstrate that defects are linked to increased dietary fatty acid fluxes toward lean organs and myocardial dysfunction in humans, suggesting that a generalized adipose tissue dysregulation of energy storage and dissipation may be at play in the development of lean tissue energy overload and lipotoxicity.
Regulation of Lipolysis By Perilipin : Influence of Obesity and Exercise Training
Exercise training increases perilipin protein content in abdominal subcutaneous adipose tissue of lean men, which appears to be a key component for a reduced β-adrenergic responsiveness in sedentary compared to lean men and it also appears that acute exercise increases ATGL and perilipIn in obese men.
Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3
It is reported that catecholamines redirect FAs for oxidation through the phosphorylation of signal transducer and activator of transcription 3 (STAT3), which inhibits the re-esterification enzyme GPAT3 via a non-genomic mechanism.


Adipocyte lipases and defect of lipolysis in human obesity.
Comparison of obese and nonobese subjects showed that obesity was associated with a decrease in catecholamine-induced lipolysis and HSL expression in mature fat cells and in differentiated preadipocytes, suggesting a possibly primary defect in obesity.
Decreased expression and function of adipocyte hormone-sensitive lipase in subcutaneous fat cells of obese subjects.
The data suggest that a decreased expression of hormone-sensitive lipase in subcutaneous fat cells, which in turn causes decreased enzyme function and impaired lipolytic capacity of adipocytes, is present in obesity.
Adipose tissue function in the insulin-resistance syndrome.
In healthy people adipose tissue blood flow is much enhanced by food intake, whereas in insulin-resistant subjects this response is blunted, which is another facet of unresponsiveness of adipose tissues in the insulin-resistance syndrome.
A pathogenic role of visceral fat beta 3-adrenoceptors in obesity.
Increased release of free fatty acids (FFA) from visceral fat cells to the portal venous system may cause several metabolic disturbances in obesity. However, this hypothesis and the underlying
Rates of skeletal muscle and adipose tissue glycerol release in nonobese and obese subjects.
It is concluded that significant amounts of glycerol are released from skeletal muscle, which suggests that muscle lipolysis provides an important endogenous energy source in humans.
Lipolysis: contribution from regional fat.
  • M. Jensen
  • Biology, Medicine
    Annual review of nutrition
  • 1997
In vitro studies of adipocytes taken from different body fat regions suggest substantial differences in lipolysis between intra-abdominal, lower-body subcutaneous, and abdominal subcutaneous regions.
Impaired β-adrenergically mediated lipolysis in skeletal muscle of obese subjects
The capacity to increase skeletal interstitial glycerol concentrations during direct β2-adrenergic stimulation is impaired in obese subjects with normal intramyocellular concentrations, suggesting that this may be an early event in the process of triglyceride accumulation.
Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase
It is reported that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis, and it is interesting that ATGL contains a “patatin domain” common to plant acyl-hydrolases.
Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis.
It is found that norepinephrine-induced lipolysis was positively correlated with HSL protein levels (P < 0.0001) but not with ATGL protein, and ATGL expression, unlike HSL, is not influenced by obesity or PCOS.
Adipose tissue metabolism in obesity: lipase action in vivo before and after a mixed meal.