Catecholamine-induced cardiac mitochondrial dysfunction and mPTP opening: protective effect of curcumin.

@article{IzemMeziane2012CatecholamineinducedCM,
  title={Catecholamine-induced cardiac mitochondrial dysfunction and mPTP opening: protective effect of curcumin.},
  author={Malika Izem-Meziane and Bahia Djerdjouri and St{\'e}phanie Rimbaud and Fanny Caffin and Dominique Fortin and Anne Garnier and Vladimir Veksler and Fr{\'e}d{\'e}ric Joubert and R Ventura-clapier},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2012},
  volume={302 3},
  pages={H665-74}
}
The present study was designed to characterize the mitochondrial dysfunction induced by catecholamines and to investigate whether curcumin, a natural antioxidant, induces cardioprotective effects against catecholamine-induced cardiotoxicity by preserving mitochondrial function. Because mitochondria play a central role in ischemia and oxidative stress, we hypothesized that mitochondrial dysfunction is involved in catecholamine toxicity and in the potential protective effects of curcumin. Male… CONTINUE READING

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