Catecholamine biosynthesis in brains of rats treated with morphine.

@article{Clouet1970CatecholamineBI,
  title={Catecholamine biosynthesis in brains of rats treated with morphine.},
  author={Doris H. Clouet and Mark Ratner},
  journal={Science},
  year={1970},
  volume={168 3933},
  pages={854-6}
}
In the brains of rats without tolerance to morphine, the accumulation of [(14)C]dopamine formed from [(14)C]tyrosine injected intracisternally is increased, reaching a maximum in the hypothalamus and striatum 1 hour after administration of morphine. In tolerant rats, the rate of incorporation of carbon-14 into dopamine and into norepinephrine in these areas is more than twice that in animals that have received only one injection of morphine. 

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