Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine

@article{Eisenhofer2004CatecholamineMA,
  title={Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine},
  author={Graeme Eisenhofer and Irwin J. Kopin and David S. Goldstein},
  journal={Pharmacological Reviews},
  year={2004},
  volume={56},
  pages={331 - 349}
}
This article provides an update about catecholamine metabolism, with emphasis on correcting common misconceptions relevant to catecholamine systems in health and disease. Importantly, most metabolism of catecholamines takes place within the same cells where the amines are synthesized. This mainly occurs secondary to leakage of catecholamines from vesicular stores into the cytoplasm. These stores exist in a highly dynamic equilibrium, with passive outward leakage counterbalanced by inward active… 

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