Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine
@article{Eisenhofer2004CatecholamineMA, title={Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine}, author={Graeme Eisenhofer and Irwin J. Kopin and David S. Goldstein}, journal={Pharmacological Reviews}, year={2004}, volume={56}, pages={331 - 349} }
This article provides an update about catecholamine metabolism, with emphasis on correcting common misconceptions relevant to catecholamine systems in health and disease. Importantly, most metabolism of catecholamines takes place within the same cells where the amines are synthesized. This mainly occurs secondary to leakage of catecholamines from vesicular stores into the cytoplasm. These stores exist in a highly dynamic equilibrium, with passive outward leakage counterbalanced by inward active…
801 Citations
The Metabolic Fate of ortho-Quinones Derived from Catecholamine Metabolites
- Chemistry, BiologyInternational journal of molecular sciences
- 2016
The fact that ortho-quinones from DOPE, DopEG, DOPAC and DOMA are converted to quinone methide tautomers as common intermediates, through proton rearrangement or decarboxylation is confirmed.
Dopamine-derived biological reactive intermediates and protein modifications: Implications for Parkinson's disease.
- Biology, ChemistryChemico-biological interactions
- 2011
Aldehyde dehydrogenase inhibition generates a reactive dopamine metabolite autotoxic to dopamine neurons.
- BiologyParkinsonism & related disorders
- 2014
Biochemical characterization of the catecholaldehyde reactivity of l-carnosine and its therapeutic potential in human myocardium
- Biology, ChemistryAmino Acids
- 2018
Carnosine was able to block formation of catecholaldehyde protein adducts in isolated human cardiac mitochondria treated with NE and, therefore, suggest a novel and distinct biological role for histidine dipeptides in this detoxification reaction.
Neurotoxicity and Metabolism of the Catecholamine-Derived 3,4-Dihydroxyphenylacetaldehyde and 3,4-Dihydroxyphenylglycolaldehyde: The Role of Aldehyde Dehydrogenase
- Chemistry, BiologyPharmacological Reviews
- 2007
This article presents a comprehensive review of what is currently known of both the neurotoxicity and respective metabolism pathways of 3,4-dihydroxyphenylacetaldehyde and 3, 4-Dihydroxybutyric aciduria with an emphasis on the role that aldehyde dehydrogenase enzymes play in the detoxification of these two aldehydes.
Monoamine oxidase A down-regulation contributes to high metanephrine concentration in pheochromocytoma.
- BiologyThe Journal of clinical endocrinology and metabolism
- 2012
High concentrations of MN in tumor do not only arise from CAT overproduction but also from low MAOA expression, resulting in higher substrate availability for COMT.
Oxidative Transformations of 3,4-Dihydroxyphenylacetaldehyde Generate Potential Reactive Intermediates as Causative Agents for Its Neurotoxicity
- Chemistry, BiologyInternational journal of molecular sciences
- 2021
DOPAL-quinone generates several toxic compounds that could augment the neurotoxicity of DOPAL, and the results indicate that the exact cause of toxicity caused by this compound remains unknown.
Pathophysiological mechanisms of catecholamine and cocaine-mediated cardiotoxicity
- BiologyHeart Failure Reviews
- 2014
The aim of the current review is to present in detail the pathophysiological processes underlying the development of catecholamine and cocaine-induced cardiomyopathy, as such conditions may be frequently encountered in the clinical practice of cardiologists and ICU specialists.
Analysis of Catecholamines and Pterins in Inborn Errors of Monoamine Neurotransmitter Metabolism—From Past to Future
- BiologyCells
- 2019
This review aims at summarizing the diverse analytical tools routinely used for diagnosis to determine quantitatively the amounts of neurotransmitters and cofactors in the different types of samples used to identify patients suffering from these rare diseases.
References
SHOWING 1-10 OF 244 REFERENCES
Evolving views of the metabolic fate of norepinephrine.
- Biology, Chemistry
- 1982
The metabolic fate of norepinephrine, which is a neurotransmitter in brain as well as at peripheral sympathetic nerve endings has been the subjects of investigation for over 25 years, and the ratio of these amines to the deaminated compounds provides a useful index of symphato-adrenal medullary activity in disease states or after drug administration.
Evolving views of the metabolic fate of norepinephrine.
- Biology, ChemistryEndocrinologia experimentalis
- 1982
The metabolic fate of norepinephrine, which is a neurotransmitter in brain as well as at peripheral sympathetic nerve endings has been the subjects of investigation for over 25 years, and the ratio of these amines to the deaminated compounds provides a useful index of symphato-adrenal medullary activity in disease states or after drug administration.
Catecholamine metabolism in neuroblastoma.
- Medicine, BiologyJournal of the National Cancer Institute
- 1976
Catecholamine monoamine oxidase a metabolite in adrenergic neurons is cytotoxic in vivo
- Biology, ChemistryBrain Research
- 2001
Acetaldehyde mediation in the mechanism of ethanol-induced changes in norepinephrine metabolism.
- Medicine, ChemistryMolecular pharmacology
- 1970
Findings confirm the hypothesis that competitive inhibition of aldehyde dehydrogenase by acetaldehyde is the quantitatively important mechansim in the genesis of altered neuroamine metabolism by ethanol.
Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones.
- Chemistry, BiologyMolecular pharmacology
- 1978
The autoxidation, periodate oxidation, and tyrosinase-mediated oxidation of 6-hydroxydopamine, dopamine, norepinephrine, and epinephrine were studied by absorption spectroscopy and gave evidence for a transient intermediate, the o -quinone, which rapidly tautomerized to the p-quinone.
Aldose reductase: An aldehyde scavenging enzyme in the intraneuronal metabolism of norepinephrine in human sympathetic ganglia
- Biology, ChemistryAutonomic Neuroscience
- 2002
TURNOVER AND METABOLISM OF CATECHOLAMINES IN PATIENTS WITH PHEOCHROMOCYTOMA.
- Medicine, BiologyThe Journal of clinical investigation
- 1964
It is concluded that in some pheochromocytomas much of the catecholamine synthesized is degraded directly in the tumor before it ever reaches the circulation, which may partially "protect" the patient from the cardiovascular effects of his tumor and thereby modify the clinical course of the disease.
Is there a third peripheral catecholaminergic system? Endogenous dopamine as an autocrine/paracrine substance derived from plasma DOPA and inactivated by conjugation.
- BiologyHypertension research : official journal of the Japanese Society of Hypertension
- 1995
Evidence suggests that in the periphery, rather than DA serving only as the precursor for the active compounds, released from sympathetic nerves and the adrenal medulla, DA may also act as an autocrine/paracrine regulator of local organ function, leading to the concept of a third peripheral catecholaminergic system.
Ethanol-induced alterations of norepinephrine metabolism in man.
- Medicine, ChemistryThe Journal of laboratory and clinical medicine
- 1967
The observed alteration of norepinephrine metabolism from the usual oxidative pathway to the reductive pathway could result in part from the increased NADH:NAD ratio resulting from ethanol metabolism or from competitive inhibition by acetaldehyde formed from the metabolism of alcohol.