Catecholamine, STH, Cortisol, Glucagon, Insulin und Sexualhormone bei körperlicher Belastung und Beta1-Blockade

  title={Catecholamine, STH, Cortisol, Glucagon, Insulin und Sexualhormone bei k{\"o}rperlicher Belastung und Beta1-Blockade},
  author={Wilfried Kindermann and Alfred Schnabel and Wolfgang M. Schmitt and G. Biro and M. Hippchen},
  journal={Klinische Wochenschrift},
SummaryThe effects of beta-1-adrenergic blockade (100 mg metoprolol) on metabolism in exercise was examined in 14 healthy males who worked for 50 min on a treadmill at 65% of their maximal exercise capacity. The tests were carried out in a double blind fashion. Glucose and lactate were determined in arterialized capillary blood, free fatty acids, glycerol, growth hormone, cortisol, glucagon, insulin, testosterone, and estradiol in serum, and adrenaline and noradrenaline in plasma.Lactate and… 
Adrenergic effects on adrenocortical cortisol response to incremental exercise to exhaustion
The data suggests a possible “ceiling” on the hypothalamic-pituitary-adrenal axis response to exercise in endurance-trained men and suggests β- adrenergic blockage and competitive conditions enhance the exercise cortisol response.


Differences in metabolic responses to beta-adrenergic stimulation after propranolol or metoprolol administration.
The two beta-receptor blockers inhibited isoprenaline-induced increase in chronotropy to about the same extent, while the effects on systolic and diastolic blood pressure were in accordance with a selective beta1-blocking effect of metoprolol and a non-selective beta-blocking action of propranolol.
Glucagon and plasma catecholamines during beta-receptor blockade in exercising man.
Neither stimulation of adrenergic receptors nor NEFA and alanine concentrations are major determinants for the exercise-induced glucagon secretion in man and it is suggested that decreased glucose availability enhances the secretion of glucagon and epinephrine during prolonged exercise.
Available evidence indicates that during prolonged exercise a-adrenergic activity inhibits insulin secretion, and in rats a- adrenergic blockade abolished the exercise-induced inhibition of insulin release.
Hemodynamic and metabolic effects of activities of the adrenergic beta receptor in physical exercise.
  • T. Hazeki
  • Medicine, Biology
    Japanese circulation journal
  • 1973
It is concluded that β-adrenergic receptor play an important role on the hemodynamic and the metabolic changes to muscular exercise and the mechanisms have been discussed.
A comparative study of serum growth hormone and plasma cortisol levels in stimulation tests with insulin and propranolol-glucagon.
Insulin and propranolol-glucagon stimulation tests were carried out on 28 children and 5 adolescents and the results of their growth hormone and plasma cortisol estimations were compared, suggesting that glucagon possesses a releasing-like mechanism which operates in the pituitary itself.
[Sympathetic responsiveness and antihypertensive effect of beta-receptor blockade in essential hypertension: the effect of atenolol (author's transl)].
The results suggest that the antihypertensive effect of atenolol is related to the responsiveness of the sympathetic nervous sytem, and Adrenergic activity is apparently an important determinant of blood pressure response to beta-blockade.
Effect of adrenergic-blocking or -stimulating agents on plasma growth hormone, immunoreactive insulin, and blood free fatty acid levels in man.
It is concluded that either beta adrenergic blockade or alpha stimulation enhances HGH secretion and inhibits insulin secretion and fat mobilization, whereas either alpha blockade or beta stimulation stimulates insulin secretionand fat mobilization and inhibits H GH secretion.
[The influence of a long-term cardioselective and noncardioselective beta-receptorblockade on blood pressure, O2-uptake and carbohydrate metabolism. Ergometric investigations in hypertensive patients (author's transl)].
The cardioselective beta-receptor blocker Metoprolol is recommended especially for the treatment of young hypertensives and for all patients who need their physical fitness in order to achieve their work or to perform a preventive and rehabilitative training.
Glucose tolerance and insulin release in hypertensive patients treated with the cardioselective beta-receptor blocking agent metoprolol.
The initial and total integrated insulin response to the i.v. administration of glucose was similar before and during metroprolol, and following oral glucose both the total integrated blood glucose response and the insulin response were unaffected by treatment with metoprolol.
[Effects of acute beta-adrenoceptor blockage (metoprolol i.v.) on plasma norepinephrine concentration and hemodynamics in postmyocardial infarction patients].
It is likely that the increased sympathetic activity after Metoprolol and during exercise is a compensatory reaction due to the hemodynamic effects of blockade of beta-adrenoceptors.