Catechol-o-Methyltransferase, Cognition, and Psychosis: Val158Met and Beyond

@article{Tunbridge2006CatecholoMethyltransferaseCA,
  title={Catechol-o-Methyltransferase, Cognition, and Psychosis: Val158Met and Beyond},
  author={E. Tunbridge and Paul J. Harrison and D. Weinberger},
  journal={Biological Psychiatry},
  year={2006},
  volume={60},
  pages={141-151}
}
This review summarizes our current understanding of catechol-o-methyltransferase (COMT) and how it relates to brain function and schizophrenia. We begin by considering the COMT gene, its transcripts and proteins, and its relevance for central catecholamine function. We then describe how variation in COMT activity affects the function of the prefrontal cortex (PFC) and associated areas, reviewing evidence that COMT modulates executive function and working memory and highlighting recent data that… Expand
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