Catechol-based substrates of chalcone synthase as a scaffold for novel inhibitors of PqsD.

  title={Catechol-based substrates of chalcone synthase as a scaffold for novel inhibitors of PqsD.},
  author={Giuseppe Allegretta and Elisabeth Weidel and Martin Empting and Rolf W. Hartmann},
  journal={European journal of medicinal chemistry},
A new strategy for treating Pseudomonas aeruginosa infections could be disrupting the Pseudomonas Quinolone Signal (PQS) quorum sensing (QS) system. The goal is to impair communication among the cells and, hence, reduce the expression of virulence factors and the formation of biofilms. PqsD is an essential enzyme for the synthesis of PQS and shares some features with chalcone synthase (CHS2), an enzyme expressed in Medicago sativa. Both proteins are quite similar concerning the size of the… CONTINUE READING
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