Catechol-based substrates of chalcone synthase as a scaffold for novel inhibitors of PqsD.

@article{Allegretta2015CatecholbasedSO,
  title={Catechol-based substrates of chalcone synthase as a scaffold for novel inhibitors of PqsD.},
  author={Giuseppe Allegretta and Elisabeth Weidel and Martin Empting and Rolf W. Hartmann},
  journal={European journal of medicinal chemistry},
  year={2015},
  volume={90},
  pages={351-9}
}
A new strategy for treating Pseudomonas aeruginosa infections could be disrupting the Pseudomonas Quinolone Signal (PQS) quorum sensing (QS) system. The goal is to impair communication among the cells and, hence, reduce the expression of virulence factors and the formation of biofilms. PqsD is an essential enzyme for the synthesis of PQS and shares some features with chalcone synthase (CHS2), an enzyme expressed in Medicago sativa. Both proteins are quite similar concerning the size of the… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 30 references

The end of an old hypothesis: the Pseudomonas signaling molecules 4-hydroxy-2alkylquinolines derive drom fatty acids, not 3-ketofatty acids

C E.Dulcey, V. Dekimpe, +6 authors E. Déziel
Chem. & Biol • 2013
View 15 Excerpts
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Overcoming the unexpected functional inversion of a PqsR antagonist

C. Lu, C K.Maurer, B. Kirsch, A. Steinbach, R W.Hartmann
Angew. Chem. Int. Ed. Engl., • 2014

Biochemical and biophysical analysis of a chiral PqsD inhibitor revealing tight-binding behavior and enantiomers with contrary thermodynamic signatures

M P.Storz, C. Brengel, +6 authors R W.Hartmann
ACS Chem. Biol., • 2013

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