Catechol adrenergic agents enhance hydroxyl radical generation in xanthine oxidase systems containing ferritin: implications for ischemia/reperfusion.

@article{Allen1994CatecholAA,
  title={Catechol adrenergic agents enhance hydroxyl radical generation in xanthine oxidase systems containing ferritin: implications for ischemia/reperfusion.},
  author={D. R. Allen and G. Wallis and P. Mccay},
  journal={Archives of biochemistry and biophysics},
  year={1994},
  volume={315 2},
  pages={
          235-43
        }
}
  • D. R. Allen, G. Wallis, P. Mccay
  • Published 1994
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
  • Iron chelators have been reported to protect tissues against reperfusion injury. This implies that iron is being released into the plasma or is made accessible in tissues for oxidation-reduction reactions. It has been postulated that ferritin is a likely source for this iron. This report demonstrates that adrenergic agents with the catechol structure, which includes the endogenous catecholamines norepinephrine and epinephrine, are capable of releasing iron from ferritin. It is shown that the… CONTINUE READING
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