Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation.

@article{Drabant2006CatecholOV,
  title={Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation.},
  author={Emily M. Drabant and Ahmad R. Hariri and Andreas Meyer-Lindenberg and Karen E. Mu{\~n}oz and Venkata S. Mattay and Bhaskar S. Kolachana and Michael F. Egan and Daniel R. Weinberger},
  journal={Archives of general psychiatry},
  year={2006},
  volume={63 12},
  pages={1396-406}
}
CONTEXT Catechol O-methyltransferase (COMT), the major enzyme determining cortical dopamine flux, has a common functional polymorphism (val(158)met) that affects prefrontal function and working memory capacity and has also been associated with anxiety and emotional dysregulation. OBJECTIVES To examine COMT val(158)met effects on corticolimbic circuitry reactivity and functional connectivity during processing of biologically salient stimuli, as well as the relationship to the temperamental… CONTINUE READING
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Association of the functional V158M catecholO-methyl-transferase polymorphism with panic disorder in women

  • K Domschke, CM Freitag, +13 authors J. Deckert
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  • 2004

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