Catechol-O-methyltransferase val 158 met genotype determines effect of reboxetine on emotional memory in healthy male volunteers

@inproceedings{Gibbs2014CatecholOmethyltransferaseV1,
  title={Catechol-O-methyltransferase val 158 met genotype determines effect of reboxetine on emotional memory in healthy male volunteers},
  author={Ayana A. Gibbs and Carla E. Bautista and Florence D. Mowlem and Kris H. Naudts and Dora T. Duka},
  year={2014}
}
The catechol-O-methyltransferase (COMT) enzyme is responsible for degradation of catecholamines, such as dopamine (DA) and noradrenaline. The substitution of methionine (met) for valine (val) at codon 158 in the COMT gene is associated with a 40% reduction in enzyme activity and higher levels of extracelluar DA. This single nucleotide polymorphism has been most extensively studied in relation to cognitive function; several studies have linked the lowactivity met allele to enhanced performance… CONTINUE READING
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COMT Val 158 Met genotype determines the direction of cognitive effects produced by catecholO - methyltransferase inhibition

SM Farrell, EM Tunbridge, S Braeutigam
Biol Psychiatry • 2012

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