Catechol-O-methyltransferase polymorphism is associated with increased uterine leiomyoma risk in different ethnic groups.

@article{AlHendy2006CatecholOmethyltransferasePI,
  title={Catechol-O-methyltransferase polymorphism is associated with increased uterine leiomyoma risk in different ethnic groups.},
  author={Ayman A Al-Hendy and Salama A. Salama},
  journal={Journal of the Society for Gynecologic Investigation},
  year={2006},
  volume={13 2},
  pages={136-44}
}
OBJECTIVES Uterine leiomyomas (ULMs) are estrogen-dependent tumors that are more common in African American women. The etiology for such ethnic disparity is currently unknown. Catechol-O-methyltransferase (COMT) is an essential enzyme in estrogen metabolism. In the current study, we investigated the association of the functional COMT Val158Met polymorphism… CONTINUE READING