Catechol-O-methyltransferase polymorphism (COMT) in suicide attempters: a possible gender effect on anger traits.

@article{Baud2007CatecholOmethyltransferaseP,
  title={Catechol-O-methyltransferase polymorphism (COMT) in suicide attempters: a possible gender effect on anger traits.},
  author={Patrick Baud and Philippe Courtet and Nader Ali Perroud and Fabrice Jollant and Catherine Buresi and Alain Malafosse},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2007},
  volume={144B 8},
  pages={1042-7}
}
Anger-related personality traits are considered contributory risk factors for suicidal behavior. According to twin studies, they are partially under genetic control and their various clinical expressions have been associated with serotonergic and catecholaminergic activities. A functional polymorphism on the human catechol-O-methyltransferase (COMT) gene, which codes for the catecholamines inactivating enzyme COMT, has been shown to influence aggressive and anger-related traits in various… CONTINUE READING