Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitivity in breast cancer survivors

  title={Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitivity in breast cancer survivors},
  author={C{\'e}sar Fern{\'a}ndez-de-Las-Pe{\~n}as and Carolina Fern{\'a}ndez-Lao and Irene Cantarero-Villanueva and Silvia Ambite-Quesada and In{\'e}s Rivas-Mart{\'i}nez and Rosario del Moral-Avila and Manuel Arroyo-Morales},
  journal={Breast Cancer Research and Treatment},
Cancer-related fatigue and pain after surgery are the most frequent and most incapacitating cancer-related symptoms after breast cancer treatment. Genetic influence of cancer-related fatigue and pain has not been previously investigated. Our aim was to examine the influence of catechol-O-methyltransferase (COMT) Val158Met genotypes on cancer-related fatigue, post-mastectomy pain, and pressure pain hypersensitivity in breast cancer survivors. One-hundred and twenty-eight (n = 128) breast cancer… CONTINUE READING


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