Catechol-O-methyltransferase gene and obsessive-compulsive symptoms in patients with recent-onset schizophrenia: preliminary results.

@article{Zinkstok2008CatecholOmethyltransferaseGA,
  title={Catechol-O-methyltransferase gene and obsessive-compulsive symptoms in patients with recent-onset schizophrenia: preliminary results.},
  author={Janneke R. Zinkstok and Lonneke J M van Nimwegen and Th{\'e}r{\`e}se A M J Van Amelsvoort and L D Dick de Haan and Maryan Abdulkadir Yusuf and Frank Baas and Don H. Linszen},
  journal={Psychiatry research},
  year={2008},
  volume={157 1-3},
  pages={1-8}
}
The catechol-O-methyltransferase (COMT) gene is a candidate gene for schizophrenia because of its role in the breakdown of dopamine in the prefrontal cortex. The COMT gene contains a functional polymorphism changing enzyme activity that has been associated with some neuropsychiatric (endo)phenotypes, e.g. cognitive performance and anxiety. In this study we investigated the association between the COMT Val(158)Met polymorphism and obsessive-compulsive symptoms in patients with schizophrenia… CONTINUE READING