Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: A large-scale association study plus meta-analysis

@article{Fan2005CatecholOmethyltransferaseGV,
  title={Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: A large-scale association study plus meta-analysis},
  author={Jin-bo Fan and Chang-Shun Zhang and Niu-fan Gu and Xing-wang Li and Wei-Wei Sun and Hongyan Wang and Guo-yin Feng and David M. St. Clair and Lin He},
  journal={Biological Psychiatry},
  year={2005},
  volume={57},
  pages={139-144}
}
BACKGROUND A common functional polymorphism (Val/Met) in the catechol-O-methyltransferase gene (COMT) that markedly affects enzyme activity has been shown to affect executive cognition and the physiology of the prefrontal cortex in humans. It is hypothesized that the high activity Val allele slightly increases risk for schizophrenia through its effect on dopamine-mediated prefrontal information processing. METHODS We compared the allele/genotype frequencies of the Val/Met polymorphism in a… Expand
Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls
TLDR
There is small but significant relationship between Val158Met genotype and executive function in healthy individuals but not in schizophrenia, and it is suggested that Val and Met alleles are codominant in their effects on cognition. Expand
The association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia.
TLDR
The findings suggest that the Val158Met polymorphism of the COMT gene might contribute to morphological abnormalities in schizophrenia. Expand
Genetic association of catechol-O-methyltransferase val(158)met polymorphism in Saudi schizophrenia patients.
TLDR
Evidence is provided for a role of the COMT Val(158)Met polymorphism in the etiopathophysiology of schizophrenia in Saudi population and it appears that the association of the Comatechol-O-methyl-transferase-like polymorphism with schizophrenia is mediated by gender. Expand
Relationship of Catechol-O-Methyltransferase Variants to Brain Structure and Function in a Population at High Risk of Psychosis
TLDR
The COMT Val allele is associated with an increased risk of schizophrenia in subjects at increased familial risk, in whom it has demonstrable effects on prefrontal brain structure and function. Expand
No association between catechol-o-methyltransferase Val108/158Met polymorphism and schizophrenia or its clinical symptomatology in a Mexican population
TLDR
It is suggested that the COMT gene may not contribute to the risk for schizophrenia among the Mexican population, and there is no evidence for an association between COMT and the clinical symptomatology of this illness. Expand
No association between catechol-o-methyltransferase Val108/158Met polymorphism and schizophrenia or its clinical symptomatology in a Mexican population
The gene coding for catecol-o-methyltransferase (COMT), participant in the metabolism of catecholamines, has long been implicated as a candidate gene for schizo- phrenia. We determined the relationExpand
Meta-Analysis of the Cognitive Effects of the Catechol-O-Methyltransferase Gene Val158/108Met Polymorphism
TLDR
Despite initially promising results, the COMT Val158/108Met polymorphism appears to have little if any association with cognitive function and publication bias may hamper attempts to understand the genetic basis of psychological functions and psychiatric disorders. Expand
Genetic Variation in Catechol-O-Methyltransferase: Effects on Working Memory in Schizophrenic Patients, Their Siblings, and Healthy Controls
TLDR
It is suggested that combinations of alleles within COMT may modulate the val(108/158)met effect in a nonlinear manner, consistent with inverted U models of dopamine signaling. Expand
Heterozygosity at catechol-O-methyltransferase Val158Met and schizophrenia: new data and meta-analysis.
TLDR
The COMT functional polymorphism rs4680 contributes to schizophrenia genetic susceptibility under an overdominant model, indicating that both too high and too low levels of dopamine signalling may be risk factors. Expand
The lack of association between catechol-O-methyltransferase (COMT) Val108/158Met and brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms and schizophrenia in a group of Turkish population
Abstract Introduction Schizophrenia is a complex neuropsychiatric disorder with deficits of multiple domains of cognitive functions, volition and emotions. Family and twin studies have providedExpand
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References

SHOWING 1-10 OF 53 REFERENCES
Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies.
TLDR
The authors suggest that case-control studies should use methods of genomic control to avoid being confounded by population stratification and call for more family-based studies to confirm the association between COMT and schizophrenia in European samples and to clarify its contribution to risk in Asian samples. Expand
Functional catechol-O-methyltransferase gene polymorphism and susceptibility to schizophrenia
TLDR
A significant combined effect was seen: the cases with concurrent family history of schizophrenia and the COMT-L allele containing genotypes had an almost 4-fold (OR=3.9, 95% CI=1.1-14.3) higher risk of schizophrenia compared to controls with theCOMT-HH genotypes. Expand
No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity.
TLDR
There was no evidence for variation in COMT activity between a group of schizophrenic patients and matched comparison subjects. Expand
Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia
TLDR
The data suggest that the COMT Val allele, because it increases prefrontal dopamine catabolism, impairs prefrontal cognition and physiology, and by this mechanism slightly increases risk for schizophrenia. Expand
Catechol‐O‐methyltransferase polymorphisms and schizophrenia: a transmission disequilibrium study in multiply affected families
TLDR
Findings may indicate an effect of COMT alleles on susceptibility to schizophrenia, or reflect linkage disequilibrium with a different causative polymorphism in the vicinity. Expand
Association study of a functional catechol-O-methyltransferase gene polymorphism in Japanese schizophrenics
TLDR
Investigating a genetic association between schizophrenia and the COMT gene polymorphism in 150 Japanese schizophrenics and controls suggests that the low activity met-108 allele may be involved in susceptibility for schizophrenia. Expand
Association Analysis of a Functional Catechol-O-Methyltransferase Gene Polymorphism in Schizophrenic Patients in Taiwan
TLDR
The results failed to show significant association between val158met polymorphism and schizophrenia, violence or suicide, however, the results showed a significant difference in age at disease onset among different genotypes. Expand
Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.
TLDR
The identification of a gentic marker associated with significant alterations in enzyme activity will facilitate the analysis of a possible role for the COMT gene in neuropsychiatric conditions in which abnormalities in catecholamine neurotransmission are believed to occur. Expand
Catechol‐O ‐methyltransferase gene polymorphism in schizophrenia: evidence for association between symptomatology and prognosis
TLDR
The findings indicate that COMT gene polymorphisms were not statistically significant between patient and control groups, however, the patients with the L/L genotype may have much more severe clinical signs in Turkish schizophrenics. Expand
Catechol-O-Methyltransferase Genotype and Dopamine Regulation in the Human Brain
TLDR
It is found that tyrosine hydroxylase mRNA in mesencephalic dopamine neurons in human brain is measured and this indicates that COMT genotype is a heritable aspect of dopamine regulation and it further explicates the mechanism by which the COMT valine allele increases susceptibility for psychosis. Expand
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