Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.

  title={Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.},
  author={John M Hettema and Seon-Sook An and J{\'o}zsef Buksz{\'a}r and Edwin J. C. G. van den Oord and Michael C. Neale and Kenneth S. Kendler and Xiangning Chen},
  journal={Biological psychiatry},
  volume={64 4},
BACKGROUND Catechol-O-methyltransferase (COMT) has been investigated for its possible role in a wide range of psychiatric phenotypes. In particular, several studies support association of this gene with panic disorder and other anxiety-related traits. METHODS We examined the COMT gene for association with genetic risk across a range of anxiety spectrum phenotypes. We used multivariate structural equation modeling to select twin pairs scoring at the extremes of a latent genetic risk factor… CONTINUE READING
42 Citations
64 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 42 extracted citations


Publications referenced by this paper.
Showing 1-10 of 64 references

O’donovan MC (2006): The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: Evidence and lessons

  • N Craddock, MJ Owen
  • Mol Psychiatry
  • 2006
Highly Influential
10 Excerpts

A population - based twin study of the relationship between neuroticism and internalizing disorders

  • S VanGestel, JJ Houwing-Duistermaat, R Adolfsson, CM vanDuijn, C VanBroeckhoven
  • Am J Psychiatry
  • 2006

Similar Papers

Loading similar papers…