Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.

@article{Hettema2008CatecholOmethyltransferaseCT,
  title={Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.},
  author={John M Hettema and Seon-Sook An and J{\'o}zsef Buksz{\'a}r and Edwin J. C. G. van den Oord and Michael C. Neale and Kenneth S. Kendler and Xiangning Chen},
  journal={Biological psychiatry},
  year={2008},
  volume={64 4},
  pages={302-10}
}
BACKGROUND Catechol-O-methyltransferase (COMT) has been investigated for its possible role in a wide range of psychiatric phenotypes. In particular, several studies support association of this gene with panic disorder and other anxiety-related traits. METHODS We examined the COMT gene for association with genetic risk across a range of anxiety spectrum phenotypes. We used multivariate structural equation modeling to select twin pairs scoring at the extremes of a latent genetic risk factor… CONTINUE READING
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