Catechol-O-methyltransferase and its inhibitors in Parkinson's disease.

  title={Catechol-O-methyltransferase and its inhibitors in Parkinson's disease.},
  author={Maria Jo{\~a}o Bonif{\'a}cio and P. Nuno Palma and Lu{\'i}s Felipe Paes de Almeida and Patr{\'i}cio Soares-da-Silva},
  journal={CNS drug reviews},
  volume={13 3},
Parkinson's disease (PD) is a neurological disorder characterized by the degeneration of dopaminergic neurons, with consequent reduction in striatal dopamine levels leading to characteristic motor symptoms. The most effective treatment for this disease continues to be the dopamine replacement therapy with levodopa together with an inhibitor of aromatic amino acid decarboxylase (AADC). The efficacy of this therapy, however, decreases with time and most patients develop fluctuating responses and… CONTINUE READING
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