Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memory.

@article{Tan2007CatecholOmethyltransferaseVM,
  title={Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memory.},
  author={Hao-Yang Tan and Qiang Chen and Terry E. Goldberg and Venkata S. Mattay and Andreas Meyer-Lindenberg and Daniel R. Weinberger and Joseph H. Callicott},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 49},
  pages={
          13393-401
        }
}
Working memory (WM) is critically mediated by dopaminergic tuning of signal-to-noise in cortical neural assemblies. However, little is known about the distributed neuronal networks impacted by dopaminergic modulation in the component processes of WM. Here, we used the genotype of the Val158Met polymorphism in catechol-O-methyltransferase (COMT) as an index of relative cortical dopamine bioavailability and tuning efficiency, to examine the spatial and subprocess specificity by which dopaminergic… CONTINUE READING

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