Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow

@article{Ho2005CatecholOmethylTV,
  title={Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow},
  author={Beng-Choon Ho and Thomas H. Wassink and Daniel S. O'Leary and Val C. Sheffield and Nancy C. Andreasen},
  journal={Molecular Psychiatry},
  year={2005},
  volume={10},
  pages={287-298}
}
The catechol-O-methyl transferase (COMT) gene is considered a leading schizophrenia candidate gene. Although its role in increasing schizophrenia susceptibility has been conflicting, recent studies suggest the valine allele may contribute to poor cognitive function in schizophrenia. V158M COMT genotype was obtained on 159 schizophrenia patients and 84 healthy controls. The effects of COMT genotype on four measures of working memory/executive functions (Wisconsin Card Sorting, digit span… CONTINUE READING
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