Catechol-O-Methyltransferase (COMT) Genotypes and Working Memory: Associations with Differing Cognitive Operations

@article{Bruder2005CatecholOMethyltransferaseG,
  title={Catechol-O-Methyltransferase (COMT) Genotypes and Working Memory: Associations with Differing Cognitive Operations},
  author={G. Bruder and J. Keilp and Hai-Min Xu and M. Shikhman and Efrat Schori and J. Gorman and T. Gilliam},
  journal={Biological Psychiatry},
  year={2005},
  volume={58},
  pages={901-907}
}
BACKGROUND Catechol-O-methyltransferase (COMT) is a strong candidate gene for schizophrenia and cognitive functions disrupted in this disorder. This report examines the relation of COMT genotypes to performance on a battery of working memory tests differing in the cognitive operations to be performed on the material. METHODS A large sample of 402 healthy adults were tested on four working memory tests: Spatial Delayed Response (SDR), Word Serial Position Test (WSPT), N-back, and Letter-Number… Expand
Count on dopamine: influences of COMT polymorphisms on numerical cognition
TLDR
The results suggest COMT-related dopaminergic modulation may be related not only to working memory, as found in previous studies, but also to the development of magnitude processing and magnitude representations. Expand
COMT val158Met and executive control: a test of the benefit of specific deficits to translational research.
TLDR
The data suggest that the interpretability gained by including task manipulations to uncover specific deficits can enhance associations between cognitive and genetic levels of analysis. Expand
Putative role of the COMT gene polymorphism (Val158Met) on verbal working memory functioning in a healthy population
  • M. Aguilera, N. Barrantes-Vidal, +6 authors L. Fañanás
  • Biology, Medicine
  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
TLDR
The Letter‐Number Sequencing task, which requires not only maintenance but also active manipulation of information seemed to be more sensitive to the disadvantageous Val/Val genotype in a large non‐clinical sample, confirming the hypothesis that Val158Met polymorphism (COMT gene) might account for individual differences on dopamine‐dependent prefrontally related neurocognitive functions. Expand
COMT genotype and cognitive function
TLDR
Findings suggest that the Val allele has a protective impact on cognitive decline in late life, and is necessary for cognitive function. Expand
The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHD
TLDR
The results are interpreted as evidence of a relationship between tonic dopamine levels associated with the met COMT allele and the maintenance of stable working memory representations required to perform the delayed-match-to-sample-task. Expand
Catechol-O-methyltransferase Val158Met genotype in healthy and personality disorder individuals: Preliminary results from an examination of cognitive tests hypothetically differentially sensitive to dopamine functions
TLDR
Both context processing and working memory appear related to COMT genotype and the AX-CPT and N-back may be most sensitive to the effects of COMT variation. Expand
Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls
TLDR
The hypothesis that functional single nucleotide polymorphism (SNP) rs4680 of the catechol-O-methyltransferase (COMT) gene could mediate the relationship between cognition and dopamine activity in the PFC is supported. Expand
Differential Effects of the Catechol-O-Methyltransferase Val158Met Genotype on the Cognitive Function of Schizophrenia Patients and Healthy Japanese Individuals
TLDR
The hypothesis that the COMT Val158Met genotype maintains an optimal level of dopamine activity is supported and is found to be associated with cognitive function in healthy controls and patients with schizophrenia. Expand
Effect of COMT val158met genotype on cognition and personality
TLDR
Higher dopamine availability of the met/met genotype enhances prefrontally mediated executive function in healthy individuals and predicts disorganized personality features, consistent with evidence from previous studies. Expand
Association of catechol-O-methyltransferase (COMT) polymorphism and academic achievement in a Chinese cohort
TLDR
Results indicated that students bearing homozygous for the Met allele tended to perform more poorly in all BCT subtests as compared to the other groups, providing evidence that affective factors might overwhelm cognitive abilities in high-stake tests like the BCT. Expand
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