Catechnolamine-cyclic-AMP-Ca2+-induced ventricular tachycardia in the intact pig heart

@article{Podzuweit1980CatechnolaminecyclicAMPCa2induce,
  title={Catechnolamine-cyclic-AMP-Ca2+-induced ventricular tachycardia in the intact pig heart},
  author={Thomas Podzuweit},
  journal={Basic Research in Cardiology},
  year={1980},
  volume={75},
  pages={772-779}
}
Agents known to increase cAMP levels in the myocardium were infused subepicaridally (focal infusion, 10 μl/min) in open-chested pigs. Infusion of noradrenalin (NA), adrenalin (10−5M each) or isoproterenol (10−6M) in the presence of Ca2+ (2.5·10−3M) consistently produced ventricular tachycardia (VT) within 60s. This tachycardia could be mimicked by electrical stimulation of the infusion area. The NA/CA2+-VT could be maintained for 30 min and was readily reversible after stopping the infusion… CONTINUE READING
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