Catechnolamine-cyclic-AMP-Ca2+-induced ventricular tachycardia in the intact pig heart

@article{Podzuweit2005CatechnolaminecyclicAMPCa2induce,
  title={Catechnolamine-cyclic-AMP-Ca2+-induced ventricular tachycardia in the intact pig heart},
  author={T. Podzuweit},
  journal={Basic Research in Cardiology},
  year={2005},
  volume={75},
  pages={772-779}
}
  • T. Podzuweit
  • Published 2005
  • Medicine
  • Basic Research in Cardiology
  • SummaryAgents known to increase cAMP levels in the myocardium were infused subepicaridally (focal infusion, 10 μl/min) in open-chested pigs. Infusion of noradrenalin (NA), adrenalin (10−5M each) or isoproterenol (10−6M) in the presence of Ca2+ (2.5·10−3M) consistently produced ventricular tachycardia (VT) within 60s. This tachycardia could be mimicked by electrical stimulation of the infusion area. The NA/CA2+-VT could be maintained for 30 min and was readily reversible after stopping the… CONTINUE READING
    Cyclic AMP mediated arrhythmias induced in the ischaemic pig heart
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 14 REFERENCES
    Differentiation of the transmembrane Na and Ca channels in mammalian cardiac fibres by the use of specific inhibitors
    • 536
    • Highly Influential