Catechin metabolites after intake of green tea infusions

  title={Catechin metabolites after intake of green tea infusions},
  author={P G Pietta and Paolo Simonetti and Claudio Gardana and Antonella Brusamolino and Paolo Morazzoni and Ezio Bombardelli},
Green tea contains relatively large amounts of catechins, that have been recognized to be efficient free‐radical scavengers. In spite of a largely described antioxidant effect, the metabolic fate of catechins in humans has been scarcely studied. An infusion of green tea (about 400 mg of catechins) was given to healthy volunteers; plasma and urine samples were collected for 5 h and 2 days, respectively. Epigallocatechin gallate and epicatechin gallate were detected in plasma samples, reaching… 
Bioavailability of tea components.
This review discusses the bioavailability of active components of green and black teas--in hot brewed tea, cold tea, and dietary supplements containing tea extracts, based on literature published in
Absorption and pharmacokinetics of green tea catechins in beagles
Green tea catechins are absorbed following an oral administration and EGC-glucuronide is the metabolic form that remains in the organism for a longer period of time, suggesting that this compound could suffer an enterohepatic cycle.
Catechins are bioavailable in men and women drinking black tea throughout the day.
Unless they are rapidly metabolized or sequestered, the catechins appeared to be absorbed in amounts that were small relative to intake, and catechin concentrations in plasma, urine and feces increased significantly relative to baseline.
Tea Catechins and Polyphenols: Health Effects, Metabolism, and Antioxidant Functions
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  • Chemistry, Medicine
    Critical reviews in food science and nutrition
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The effects of tea and green tea catechins on biomarker of oxidative stress, especially oxidative DNA damage, appear very promising in animal models, but data on biomarkers of in vivo oxidative stress in humans are limited.
Bolus ingestion of white and green tea increases the concentration of several flavan-3-ols in plasma, but does not affect markers of oxidative stress in healthy non-smokers.
Conclusions with respect to health protective effects of WT and GT on the basis of these biomarkers can, thus, not be drawn.
Biomarkers of tea and coffee-derived polyphenol exposure in human subjects
Tea and coffee are rich in polyphenols with a variety of biological activities. Polyphenols found in tea are predominantly flavonoids, of which up to 15% are present as free or esterified gallic
Identification of the major antioxidative metabolites in biological fluids of the rat with ingested (+)-catechin and (-)-epicatechin.
It is concluded that (+)-catechin 5-O-beta-glucuronide and (-)-epicatechin 5 -O- beta-glUCuronide are the biologically active in vivo structures of the ingested polyphenolic antioxidants.
Epicatechin in human plasma: in vivo determination and effect of chocolate consumption on plasma oxidation status.
The data support the concept that the consumption of chocolate can result in significant increases in plasma epicatechin concentrations and decreases in plasma baseline oxidation products.


Identification of Gingko biloba flavonol metabolites after oral administration to humans.
Analysis of plasma and urinary tea polyphenols in human subjects.
  • M. Lee, Z. Y. Wang, C. S. Yang
  • Chemistry, Medicine
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 1995
Methods for the analysis of tea polyphenols in human plasma and urine samples using HPLC with the coulochem electrode array detection system to develop biomarkers for tea consumption established good quantitative relationships for a large concentration range of teapolyphenols.
Dietary flavonoids and interaction with endogenous antioxidants
Green tea catechins were given to healthy volunteers under controlled diet for 4 consecutive weeks. Plasma concentrations of ascorbate, urate, α‐tocopherol, β‐carotene and blood levels of total
Protective effect of epicatechin, epicatechin gallate, and quercetin on lipid peroxidation in phospholipid bilayers.
It is concluded that catechins and quercetin serve as powerful antioxidants against lipid peroxidation when phospholipid bilayers are exposed to aqueous oxygen radicals.
Antioxidant activity of various tea extracts in relation to their antimutagenicity
The relationship between antioxidant activity and antimutagenicity of various tea extracts (green tea, pouchong tea, oolong tea, and black tea) was investigated. All tea extracts exhibited markedly
Evaluation of the antioxidant and prooxidant actions of gallic acid and its derivatives
The antioxidant and prooxidant activities of gallic acid and its propyl, methyl, and (where solubility allowed) lauryl esters were investigated. Gallic acid (GA), propyl gallate (PG), and gallic acid
Evaluation of the Total Antioxidant Activity as a Marker of the Deterioration of Apple Juice on Storage
The total antioxidant activity (TAA) has been evaluated as a marker of the deterioration of apple juice during storage. Unfortified juice, juice fortified with vitamin C, and an apple drink (6%
Plant Flavonoids, Especially Tea Flavonols, Are Powerful Antioxidants Using an in Vitro Oxidation Model for Heart Disease
Flavonoids, commonly occurring antioxidants in foods, have been compared in a dose-response manner with vitamins C and E and beta-carotene and found to be powerful antioxidants using an in vitro
Health implications of Mediterranean diets in light of contemporary knowledge. 1. Plant foods and dairy products.
The abundant fruit, vegetables, and whole grains, and the low to moderate intake of dairy products in traditional Mediterranean diets are likely to have contributed to the low rates of numerous chronic diseases observed in these populations.