Catechin Hydrate Ameliorates Redox Imbalance and Limits Inflammatory Response in Focal Cerebral Ischemia

@article{Ashafaq2012CatechinHA,
  title={Catechin Hydrate Ameliorates Redox Imbalance and Limits Inflammatory Response in Focal Cerebral Ischemia},
  author={Mohammad Ashafaq and Syed Shadab Raza and Mohd. Moshahid Khan and Ajmal Ahmad and H. T. Javed and Md. Ejaz Ahmad and Rizwana Tabassum and Farah Islam and Mohammad Saeed Siddiqui and Mohammed M Safhi and Fakhrul Islam},
  journal={Neurochemical Research},
  year={2012},
  volume={37},
  pages={1747-1760}
}
Epidemiologic studies have shown that foods rich in polyphenols, such as flavonoids, can lower the risk of ischemic disease; however, the mechanism of protection has not been clearly investigated. In this study, we hypothesized that pretreatment effect of catechin hydrate (CH) on functional outcome, neuronal damage and on secondary injuries in the ischemic brain of rats. To test this hypothesis, male Wistar rats were pretreated with CH (20 mg/kg b.wt) for 21 days and then subjected to 2 h… CONTINUE READING

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