Catch-up growth and obesity in male mice

@article{Ozanne2004CatchupGA,
  title={Catch-up growth and obesity in male mice},
  author={Susan E. Ozanne and Charles Nicholas Hales},
  journal={Nature},
  year={2004},
  volume={427},
  pages={411-412}
}
Poor fetal growth is linked with long-term detrimental effects on health in adulthood1. Here we investigate whether the lifespan of male mice is affected by their growth rate when they were suckling and find that limiting growth during that period not only increases longevity but also protects against the life-shortening effect of an obesity-inducing diet later on. By contrast, we find that lifespan is considerably shortened if the postnatal period of growth is accelerated to make up for… 
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Increased adiposity programmed by catch-up growth: requirement for leptin signals?
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Forced catch-up growth after fetal protein restriction alters the adipose tissue gene expression program leading to obesity in adult mice.
TLDR
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It is shown that low birth weight followed by rapid catch-up growth during lactation (recuperated offspring) leads to a persistent increase in body weight in adult life, both in wild-type and ob/ob animals.
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