Catapulting clopidogrel pharmacogenomics forward

@article{Topol2011CatapultingCP,
  title={Catapulting clopidogrel pharmacogenomics forward},
  author={Eric J. Topol and Nicholas J. Schork},
  journal={Nature Medicine},
  year={2011},
  volume={17},
  pages={40-41}
}
The antiplatelet drug clopidogrel helps prevent stent-associated thrombosis, but the antiplatelet effects are quite variable and the clinical consequences can be serious. New findings show that the variability in clopidogrel efficacy is affected by the enzyme paraoxonase-1 (PON1), which is required for clopidogrel bioactivation (pages 110–116 ). 
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