Cataplexy-Active Neurons in the Hypothalamus Implications for the Role of Histamine in Sleep and Waking Behavior

@article{John2004CataplexyActiveNI,
  title={Cataplexy-Active Neurons in the Hypothalamus Implications for the Role of Histamine in Sleep and Waking Behavior},
  author={Joshi John and Ming-Fung Wu and Lisa N Boehmer and Jerome M Siegel},
  journal={Neuron},
  year={2004},
  volume={42},
  pages={619-634}
}
Noradrenergic, serotonergic, and histaminergic neurons are continuously active during waking, reduce discharge during NREM sleep, and cease discharge during REM sleep. Cataplexy, a symptom associated with narcolepsy, is a waking state in which muscle tone is lost, as it is in REM sleep, while environmental awareness continues, as in alert waking. In prior work, we reported that, during cataplexy, noradrenergic neurons cease discharge, and serotonergic neurons greatly reduce activity. We now… CONTINUE READING