Catalyzed selective direct α- and γ-alkylation of aldehydes with cyclic benzyl ethers by using T(+)BF4- in the presence of an inexpensive organic acid or anhydride.

@article{Richter2011CatalyzedSD,
  title={Catalyzed selective direct α- and γ-alkylation of aldehydes with cyclic benzyl ethers by using T(+)BF4- in the presence of an inexpensive organic acid or anhydride.},
  author={H. Richter and Renate Rohlmann and O. Garc{\'i}a Manche{\~n}o},
  journal={Chemistry},
  year={2011},
  volume={17 41},
  pages={
          11622-7
        }
}
  • H. Richter, Renate Rohlmann, O. García Mancheño
  • Published 2011
  • Medicine, Chemistry
  • Chemistry
  • The cross dehydrogenative coupling (CDC) of cyclic benzyl ethers with aliphatic and α,β-unsaturated aldehydes has been developed. The mild reaction conditions, in which an N-oxoammonium salt derived from TEMPO (2,2,6,6-tetramethyl-1-piperidinoxyl) is employed as the oxidant in combination with a Cu catalyst, allow the use of relatively redox-unstable aldehydes under oxidative CDC conditions. The addition of a catalytic amount of trifluoroacetic acid (TFA) or Ac(2)O facilitates the reaction and… CONTINUE READING
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