Catalytic surface radical in dye-decolorizing peroxidase: a computational, spectroscopic and site-directed mutagenesis study

@article{Linde2015CatalyticSR,
  title={Catalytic surface radical in dye-decolorizing peroxidase: a computational, spectroscopic and site-directed mutagenesis study},
  author={D. Linde and R. Pogni and M. Ca{\~n}ellas and F{\'a}tima Lucas and V. Guallar and M. C. Baratto and A. Sinicropi and Ver{\'o}nica S{\'a}ez-Jim{\'e}nez and Cristina Coscol{\'i}n and A. Romero and F. Medrano and F. J. Ruiz-Due{\~n}as and A. Mart{\'i}nez},
  journal={Biochemical Journal},
  year={2015},
  volume={466},
  pages={253 - 262}
}
  • D. Linde, R. Pogni, +10 authors A. Martínez
  • Published 2015
  • Medicine, Chemistry
  • Biochemical Journal
  • Dye-decolorizing peroxidase (DyP) of Auricularia auricula-judae has been expressed in Escherichia coli as a representative of a new DyP family, and subjected to mutagenic, spectroscopic, crystallographic and computational studies. The crystal structure of DyP shows a buried haem cofactor, and surface tryptophan and tyrosine residues potentially involved in long-range electron transfer from bulky dyes. Simulations using PELE (Protein Energy Landscape Exploration) software provided several… CONTINUE READING

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