Catalytic sites for 3' and 5' incision of Escherichia coli nucleotide excision repair are both located in UvrC.

@article{Verhoeven2000CatalyticSF,
  title={Catalytic sites for 3' and 5' incision of Escherichia coli nucleotide excision repair are both located in UvrC.},
  author={Esther E A Verhoeven and Marian van Kesteren and Geri F. Moolenaar and Robert Visse and N. Goosen},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 7},
  pages={5120-3}
}
Nucleotide excision repair in Escherichia coli is a multistep process in which DNA damage is removed by incision of the DNA on both sides of the damage, followed by removal of the oligonucleotide containing the lesion. The two incision reactions take place in a complex of damaged DNA with UvrB and UvrC. It has been shown (Lin, J. -J., and Sancar, A. (1992) J. Biol. Chem. 267, 17688-17692) that the catalytic site for incision on the 5' side of the damage is located in the UvrC protein. Here we… CONTINUE READING

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