Catalytic significance of the specificity of divalent cations as KS* and kcat* cofactors for secreted phospholipase A2.

Abstract

Calcium is required for the substrate binding and for the chemical step of the interfacial catalytic turnover cycle of pancreatic phospholipase A2 (PLA2), but not for the binding of the enzyme to the interface. The role of calcium and other divalent cations (C) is analyzed for the effect on the substrate binding and kcat* for the chemical step. The cofactor… (More)

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