Catalytic self-assembly of a DNA dendritic complex for efficient gene silencing.


A catalytic self-assembled DNA dendritic complex was herein reported and used for siRNA-based gene silencing. This kind of one-pot DNA dendrimer can be conveniently prepared as needed, and it was demonstrated to have better silencing efficiency and lower cytotoxicity than commercial cationic lipid transfection agents. 
DOI: 10.1039/c5cc06937h