Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin.

  title={Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin.},
  author={Heleen Heyn and Rebecca M B White and Jeffrey C. Stevens},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={24 9},
In vitro methods were used to identify the cytochrome P450 (CYP) enzyme(s) involved in S-mephenytoin N-demethylation. S-Mephenytoin (200 microM) was incubated with human liver microsomes, and nirvanol formation was quantitated by reversed-phase HPLC. S-Mephenytoin N-demethylase activity in a panel of human liver microsomes ranged 35-fold from 9 to 319 pmol/min/mg protein and correlated strongly with microsomal CYP2B6 activity (r = 0.91). Additional correlations were found with microsomal CYP2A6… CONTINUE READING
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