Catalytic properties of class A beta-lactamases: efficiency and diversity.

  title={Catalytic properties of class A beta-lactamases: efficiency and diversity.},
  author={Andr{\'e} Matagne and Josette Lamotte-Brasseur and Jean Marie Fr{\`e}re},
  journal={The Biochemical journal},
  volume={330 ( Pt 2)},
beta-Lactamases are the main cause of bacterial resistance to penicillins, cephalosporins and related beta-lactam compounds. These enzymes inactivate the antibiotics by hydrolysing the amide bond of the beta-lactam ring. Class A beta-lactamases are the most widespread enzymes and are responsible for numerous failures in the treatment of infectious diseases. The introduction of new beta-lactam compounds, which are meant to be 'beta-lactamase-stable' or beta-lactamase inhibitors, is thus… CONTINUE READING

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