Catalytic properties of NAD(P)H:quinone acceptor oxidoreductase: study involving mouse, rat, human, and mouse-rat chimeric enzymes.

Abstract

NAD(P):quinone acceptor oxidoreductase (quinone reductase) (DT-diaphorase, EC 1.6.99.2) is involved in the process of reductive activation of cytotoxic antitumor quinones and nitrobenzenes. In this study, we initially examined the relative abilities of mouse, rat, and human quinone reductases to reduce two prodrugs, CB 1954 [5-(aziridin-1-yl)-2,4… (More)

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@article{Chen1995CatalyticPO, title={Catalytic properties of NAD(P)H:quinone acceptor oxidoreductase: study involving mouse, rat, human, and mouse-rat chimeric enzymes.}, author={S Chen and Richard Knox and Adam D Lewis and Frank Friedlos and Paul Workman and Peter Shaohua Deng and May Fung and Donna M. Ebenstein and K. Chauncey Wu and T M Tsai}, journal={Molecular pharmacology}, year={1995}, volume={47 5}, pages={934-9} }