Catalytic metalloporphyrin protects against paraquat neurotoxicity in vivo.

@article{Chen2008CatalyticMP,
  title={Catalytic metalloporphyrin protects against paraquat neurotoxicity in vivo.},
  author={Ping Chen and Zhen Chen and Ang Li and Xiao-Chu Lou and Xiao-kang Wu and Chun-jun Zhao and Shi-long Wang and Li-ping Liang},
  journal={Biomedical and environmental sciences : BES},
  year={2008},
  volume={21 3},
  pages={
          233-8
        }
}
OBJECTIVE To examine the neuroprotective effects of a novel manganese porphyrin, manganese (III) meso-tetrakis (N,N'-diethylimidazolium-2-yl) porphyrin (MnTDM), in the mouse model of Parkinson's disease (PD) induced by paraquat (PQ). METHODS Male C57BL/6 mice were subcutaneously injected with either saline or PQ at 2-day intervals for a total of 10 doses, MnTDM was subcutaneously injected with the PQ 2 h before treatment. Performance on the pole and swim test were measured 7 days after the… CONTINUE READING

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