Catalytic mechanisms for phosphotriesterases.

@article{Bigley2013CatalyticMF,
  title={Catalytic mechanisms for phosphotriesterases.},
  author={Andrew N Bigley and Frank M Raushel},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1834 1},
  pages={443-53}
}
Phosphotriesters are one class of highly toxic synthetic compounds known as organophosphates. Wide spread usage of organophosphates as insecticides as well as nerve agents has lead to numerous efforts to identify enzymes capable of detoxifying them. A wide array of enzymes has been found to have phosphotriesterase activity including phosphotriesterase (PTE), methyl parathion hydrolase (MPH), organophosphorus acid anhydrolase (OPAA), diisopropylfluorophosphatase (DFP), and paraoxonase 1 (PON1… CONTINUE READING

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