Catalytic mechanism of stereospecific formation of cis-configured prenylated pyrroloindoline diketopiperazines by indole prenyltransferases.

Abstract

Indole prenyltransferases AnaPT, CdpC3PT, and CdpNPT are known to catalyze the formation of prenylated pyrroloindoline diketopiperazines from tryptophan-containing cyclic dipeptides in one-step reactions. In this study, we investigated the different stereoselectivities of these enzymes toward all the stereoisomers of cyclo-Trp-Ala and cyclo-Trp-Pro. The… (More)
DOI: 10.1016/j.chembiol.2013.10.007

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Cite this paper

@article{Yu2013CatalyticMO, title={Catalytic mechanism of stereospecific formation of cis-configured prenylated pyrroloindoline diketopiperazines by indole prenyltransferases.}, author={Xia Yu and Georg E Zocher and Xiulan Xie and Mike Liebhold and Stefan Schuetz and Thilo Stehle and Shu-Ming Li}, journal={Chemistry & biology}, year={2013}, volume={20 12}, pages={1492-501} }