Catalytic mechanism of hamster arylamine N-acetyltransferase 2.

Abstract

Arylamine N-acetyltransferases (NATs) catalyze an acetyl group transfer from AcCoA to primary arylamines, hydrazines, and hydrazides and play a very important role in the metabolism and bioactivation of drugs, carcinogens, and other xenobiotics. The reaction follows a ping-pong bi-bi mechanism. Structure analysis of bacterial NATs revealed a Cys-His-Asp… (More)

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Cite this paper

@article{Wang2005CatalyticMO, title={Catalytic mechanism of hamster arylamine N-acetyltransferase 2.}, author={Haiqing Wang and Li Liu and Patrick E. Hanna and Carston R Wagner}, journal={Biochemistry}, year={2005}, volume={44 33}, pages={11295-306} }