Catalytic mechanism of cofactor-free dioxygenases and how they circumvent spin-forbidden oxygenation of their substrates.

@article{HernndezOrtega2015CatalyticMO,
  title={Catalytic mechanism of cofactor-free dioxygenases and how they circumvent spin-forbidden oxygenation of their substrates.},
  author={Aitor Hern{\'a}ndez-Ortega and Matthew G Quesne and Soi H Bui and Derren J Heyes and Roberto A Steiner and Nigel S. Scrutton and Sam P de Visser},
  journal={Journal of the American Chemical Society},
  year={2015},
  volume={137 23},
  pages={7474-87}
}
Dioxygenases catalyze a diverse range of biological reactions by incorporating molecular oxygen into organic substrates. Typically, they use transition metals or organic cofactors for catalysis. Bacterial 1-H-3-hydroxy-4-oxoquinaldine-2,4-dioxygenase (HOD) catalyzes the spin-forbidden transfer of dioxygen to its N-heteroaromatic substrate in the absence of any cofactor. We combined kinetics, spectroscopic and computational approaches to establish a novel reaction mechanism. The present work… CONTINUE READING
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