Catalytic mechanism of a mammalian Rab·RabGAP complex in atomic detail.

  title={Catalytic mechanism of a mammalian Rab·RabGAP complex in atomic detail.},
  author={Konstantin Gavriljuk and Emerich-Mihai Gazdag and Aymelt Itzen and Carsten K{\"o}tting and Roger S. Goody and Klaus Gerwert},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 52},
Rab GTPases, key regulators of vesicular transport, hydrolyze GTP very slowly unless assisted by Rab GTPase-activating proteins (RabGAPs). Dysfunction of RabGAPs is involved in many diseases. By combining X-ray structure analysis and time-resolved FTIR spectroscopy we reveal here the detailed molecular reaction mechanism of a complex between human Rab and RabGAP at the highest possible spatiotemporal resolution and in atomic detail. A glutamine residue of Rab proteins (cis-glutamine) that is… CONTINUE READING


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