Catalytic mechanism of α-class carbonic anhydrases: CO2 hydration and proton transfer.

@article{Boone2014CatalyticMO,
  title={Catalytic mechanism of α-class carbonic anhydrases: CO2 hydration and proton transfer.},
  author={Christopher D. Boone and Melissa A Pinard and R. V. McKenna and David Silverman},
  journal={Sub-cellular biochemistry},
  year={2014},
  volume={75},
  pages={31-52}
}
The carbonic anhydrases (CAs; EC 4.2.1.1) are a family of metalloenzymes that catalyze the reversible hydration of carbon dioxide (CO2) and dehydration of bicarbonate (HCO3 (-)) in a two-step ping-pong mechanism: [Formula: see text] CAs are ubiquitous enzymes and are categorized into five distinct classes (α, β, γ, δ and ζ). The α-class is found primarily in vertebrates (and the only class of CA in mammals), β is observed in higher plants and some prokaryotes, γ is present only in… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Crystallography and Its Impact on Carbonic Anhydrase Research

International journal of medicinal chemistry • 2018
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…