Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone.

@article{Steinchen2015CatalyticMA,
  title={Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone.},
  author={Wieland Steinchen and Jan Schuhmacher and Florian Altegoer and Christopher D. Fage and Vasundara Srinivasan and Uwe Linne and Mohamed A. Marahiel and Gert Bange},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 43},
  pages={13348-53}
}
Nucleotide-based second messengers serve in the response of living organisms to environmental changes. In bacteria and plant chloroplasts, guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) [collectively named "(p)ppGpp"] act as alarmones that globally reprogram cellular physiology during various stress conditions. Enzymes of the RelA/SpoT homology (RSH) family synthesize (p)ppGpp by transferring pyrophosphate from ATP to GDP or GTP. Little is known about the catalytic… CONTINUE READING
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