Catalytic inhibition of human DNA topoisomerase IIalpha by hypericin, a naphthodianthrone from St. John's wort (Hypericum perforatum).

@article{Peebles2001CatalyticIO,
  title={Catalytic inhibition of human DNA topoisomerase IIalpha by hypericin, a naphthodianthrone from St. John's wort (Hypericum perforatum).},
  author={Katherine A Peebles and Robert K Baker and Ebba U. Kurz and B J Schneider and David J. Kroll},
  journal={Biochemical pharmacology},
  year={2001},
  volume={62 8},
  pages={1059-70}
}
St. John's wort (Hypericum perforatum) is the most widely used herbal medicine for the treatment of depression. However, concerns have arisen about the potential of its interaction with other drugs due to the induction of cytochrome P450 isozymes 1A2 and 3A4 by the components hypericin and hyperforin, respectively. Structurally similar natural products are often employed as antitumor agents due to their action as inhibitors of DNA topoisomerases, nuclear enzymes that modify DNA during cellular… CONTINUE READING

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Structurally similar natural products are often employed as antitumor agents due to their action as inhibitors of DNA topoisomerases , nuclear enzymes that modify DNA during cellular proliferation .
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