Catalytic inactive heme oxygenase-1 protein regulates its own expression in oxidative stress.

@article{Lin2008CatalyticIH,
  title={Catalytic inactive heme oxygenase-1 protein regulates its own expression in oxidative stress.},
  author={Qing Sara Lin and Sebastian Weis and Guang Yang and Tiangang Zhuang and Aida Abate and Phyllis A. Dennery},
  journal={Free radical biology & medicine},
  year={2008},
  volume={44 5},
  pages={847-55}
}
Heme oxygenase-1 (HO-1) catalyzes the degradation of heme and forms antioxidant bile pigments as well as the signaling molecule carbon monoxide. HO-1 is inducible in response to a variety of chemical and physical stress conditions to function as a cytoprotective molecule. Therefore, it is important to maintain the basal level of HO-1 expression even when substrate availability is limited. We hypothesized that the HO-1 protein itself could regulate its own expression in a positive feedback… CONTINUE READING