Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus.

@article{BezSantos2014CatalyticFA,
  title={Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus.},
  author={Yahira M. B{\'a}ez-Santos and Anna Maria Mielech and Xufang Deng and Susan C Baker and Andrew D. Mesecar},
  journal={Journal of virology},
  year={2014},
  volume={88 21},
  pages={12511-27}
}
UNLABELLED The papain-like protease (PLpro) domain from the deadly Middle East respiratory syndrome coronavirus (MERS-CoV) was overexpressed and purified. MERS-CoV PLpro constructs with and without the putative ubiquitin-like (UBL) domain at the N terminus were found to possess protease, deubiquitinating, deISGylating, and interferon antagonism activities in transfected HEK293T cells. The quaternary structure and substrate preferences of MERS-CoV PLpro were determined and compared to those of… CONTINUE READING
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